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Alzheimer's drug promises to slow worsening but with safety concern

Published Sat, 22 Feb 2025 04:13:30 GMT

WASHINGTON (AP) — Another experimental Alzheimer’s drug can modestly slow patients’ inevitable worsening — by about four to seven months, researchers reported Monday.Eli Lilly and Co. is seeking Food and Drug Administration approval of donanemab. If cleared, it would be only the second Alzheimer’s treatment convincingly shown to delay the mind-robbing disease — after the recently approved Leqembi from Japanese drugmaker Eisai. Law enforcement trade Taylor Swift friendship bracelets at Denver Eras Tour stop “Finally there's some hope, right, that we can talk about," Lilly's Dr. John Sims told reporters Monday at the Alzheimer's Association International Conference in Amsterdam. “We don't cure the disease,” he said. “Diabetes doesn't have a cure either — it doesn't mean you can't have very meaningful treatments for patients.”Lilly announced in May that donanemab appeared to work, but on Monday the full results of a study of 1,700 patients was published by the Journal of the American...

Police search for purse thief in Miramar

Published Sat, 22 Feb 2025 04:13:30 GMT

A purse thief was caught on camera in Miramar.Video from Wednesday morning showed a person getting out of a car at a gas station, located at o 3100 SW 148th Ave.The suspect was seen opening the victim’s door, reached inside and took the purse that was on the passenger seat.Police posted video on social media.7News has reached out to police for more information. They have not identified the suspect. If you have any information on this crime, call Broward County Crime Stoppers at 954-493-TIPS. Remember, you can always remain anonymous, and you may be eligible for a reward of up to $5,000.

Ben Wallace is quitting as UK defense secretary. Here’s who might replace him

Published Sat, 22 Feb 2025 04:13:30 GMT

LONDON — Ben Wallace is on the way out as U.K. defense secretary. Attention is already turning to who comes next.Wallace — whose international reputation has been bolstered by the war in Ukraine — announced in a Sunday Times interview that he will resign as defense chief and eventually quit British politics altogether.The jostling to replace him has already started — with prominent Tories well aware that helming the Ministry of Defence during war-time can do wonders for your reputation. Here are the runners and riders to be the next person in charge of U.K. defense.John GlenMuch of Wallace’s tenure was marked by tension between the MoD — pushing to increase capacity — and the bean counters at the Treasury, determined to keep the country’s multibillion-pound defense budget in check.Prime Minister Rishi Sunak could always resolve that tension by … installing a bean counter at the MoD. One name in the frame is John Glen, currently second-in-command to Chancellor Jerem...

Second Alzheimer’s drug to slow disease’s progression may be approved in the US this year

Published Sat, 22 Feb 2025 04:13:30 GMT

(CNN) — The full approval this month of the Alzheimer’s drug Leqembi marked a historic shift in the treatment of the disease: For the first time, doctors have a medicine to prescribe that has been proven to slow the loss of memory and ability to do daily tasks that Alzheimer’s brings.A second drug may join Leqembi — known as lecanemab before it got its brand name — on the market by the end of the year: Eli Lilly’s donanemab.It was shown in May and in fuller Phase 3 clinical trial results released at the Alzheimer’s Association International Conference on Monday to delay the disease’s progression. Lilly said in a news release that it had completed its US Food and Drug Administration submission for the drug, and expects regulatory action by year’s end.More than 6 million Americans are estimated to have Alzheimer’s disease, with about 1 million estimated to be in the early symptomatic stages where these drugs have shown benefit. But even though the medicines ar...

Spotlight on judge in Trump documents case intensifies following controversial earlier ruling

Published Sat, 22 Feb 2025 04:13:30 GMT

By ERIC TUCKER and ADRIANA GOMEZ LICON (Associated Press)MIAMI (AP) — A month after former President Donald Trump was charged with mishandling classified documents, the judge presiding over the case is set to take on a more visible role as she weighs competing requests on a trial date and hears arguments this week on a procedural, but potentially crucial, area of the law.A pretrial conference Tuesday to discuss procedures for handling classified information will represent the first courtroom arguments in the case before U.S. District Judge Aileen Cannon since Trump was indicted five weeks ago. The arguments could provide insight into how Cannon intends to preside over the case while she also confronts the unresolved question of how to schedule Trump’s trial as he campaigns for president.Those issues would be closely watched in any trial involving a former president. But Cannon could face additional scrutiny in light of a much-dissected ruling she issued last year that gr...

Mets outlast rain, walk-off Dodgers in 10 innings

Published Sat, 22 Feb 2025 04:13:30 GMT

It took a four-hour rain delay and extra innings, but the Mets managed to salvage a series against the Los Angeles Dodgers on Sunday afternoon at Citi Field with a 2-1 walk-off win.Luis Guillorme pinch-hit to lead off the 10th with the Mets sending him out to bunt. His first two went foul against right-hander Nick Robertson (0-1), but it didn’t matter. He ripped a double down the right side to score the automatic runner and halt the Mets’ losing streak at four games.“The bunt didn’t really work,” Guillorme said. “Then he just threw one in to me and I tried to get out of the way but that didn’t work out either. All I was trying to do was get a ground ball to the right side. It worked out.”Max Scherzer pitched seven innings of one-hit baseball against his former team, holding them scoreless while striking out six and walking three in a performance that manager Buck Showalter called “outstanding.”Scherzer finally managed to ge...

Dylan Cease earns first win since May as the Chicago White Sox top the Atlanta Braves 8-1 to take the series

Published Sat, 22 Feb 2025 04:13:30 GMT

Dylan Cease is a native of Milton, Ga., which is about 25 miles from Truist Park.With an estimated 30 to 40 people he knew in the stands, the Chicago White Sox starter faced the Atlanta Braves for the first time in his career Sunday.“It was really cool,” Cease said. “I never went to Truist growing up, I was always at Turner Field. But it’s still great to pitch at my hometown ballpark.”Cease received a ton of offensive support on the way to his first victory since May 23, as the Sox topped the Braves 8-1 in front of 40,174.The win capped one of the better series of the season for the Sox. They took two of three for their first series victory since June 23-25 against Boston and their first one on the road since June 6-8 at Yankee Stadium.“Our bats were there, we played great defense, our pitching was solid,” Cease said. “It’s one of those series that shows the kind of talent we have.”Saturday, the Sox snapped Atlanta’s ...

Stock market today: Wall Street ticks higher as earnings season ramps up

Published Sat, 22 Feb 2025 04:13:30 GMT

NEW YORK (AP) — Wall Street is edging higher Monday ahead of a week full of updates about where profits for big U.S. companies are heading. The S&P 500 was up 0.3% in midday trading, coming off its seventh winning week in the last nine. The Dow Jones Industrial Average was up 65 points , or 0.2%, at 34,574, as of 11:30 a.m. Eastern time, and the Nasdaq composite was 0.6% higher.Stocks elsewhere around the world slipped after China reported weaker economic growth for the spring than economists expected. Its recovery following the removal of anti-COVID restrictions has fallen short of forecasts. While that’s helped to limit inflation globally, it’s also diluted a main engine of growth for the world’s economy.The weak data from the world’s second-largest economy helped weigh on crude prices, with benchmark U.S. oil slipping 0.8% to $74.82 per barrel. Brent crude, the international standard, fell 0.9% to $79.16 per barrel. The hope among investors is that the disappointing fig...

Nicolas Cage to skip Fantasia Festival in Montreal due to SAG-ACTRA strike

Published Sat, 22 Feb 2025 04:13:30 GMT

MONTREAL — A Montreal film festival says Nicolas Cage will no longer make an appearance due to the Hollywoodactors’ strike.Cage had been set to receive the career achievement award at the Fantasia International Film Festival, which celebrates genre cinema such as horror and science fiction.Cage’s latest film, “Sympathy for the Devil,” is to premiere at the festival on Saturday, but he will no longer be in attendance. The performers union SAG-AFTRA began a strike last Friday, and its rules prohibit members from promoting studio films.In a notice on its website, Fantasia says it will provide regular updates about other SAG members who had planned to attend.The festival, which runs from July 20 to Aug. 9, says it supports the actors, as well as the striking Writers Guild of America, and hopes the unions get a fair deal soon.This report by The Canadian Press was first published July 17, 2023.The Canadian Press

Hollywood plunges into all-out war on the heels of pandemic and a streaming revolution

Published Sat, 22 Feb 2025 04:13:30 GMT

NEW YORK (AP) — To get a sense of just how much animosity is flying around Hollywood these days, watch how Ron Perlman responded to a report that the studios aimed to prolong a strike long enough for writers to lose their homes.Perlman, the hulking, gravel-voiced actor of “Hellboy,” leaned into the camera in a since-deleted Instagram live video to vent his anger. “Listen to me, mother-(expletive),” Perlman said. “There’s a lot of ways to lose your house.”Three years after the pandemic brought Hollywood to a standstill, the film and TV industry has again ground to a halt. This time, though, the industry is engaged in a bitter battle over the how streaming — after advancing rapidly during the pandemic — has upended the economics of entertainment.Having weathered plague, Hollywood is now fully at war in its own “Apocalypse Now” double feature. When tens of thousands Screen Actors Guild-American Federation of Television and Radio Artist hit the picket lines last week, joining 11,000 WGA...